Uncovering circuits, cells, and molecular pathways underlying the pathogenesis of Huntington’s disease, with the goal of finding therapeutics targets.

Studying basal ganglia circuitry to shed light on normal behavior, psychiatric disorders, and addiction.

MORF (MOnonucleotide Repeat Frameshift) is a powerful Cre-dependent sparse cell labeling methodology developed by the Yang lab to reveal the brainwide, intricate morphology or hundreds to thousands of genetically-defined neurons or glial cells.